Bisphenol A accumulation in eggs disrupts the endocrine regulation of growth in rainbow trout larvae

Bisphenol A (BPA), a monomer used in the production of plastics and epoxy resins, is ubiquitously present in the aquatic environment. BPA is considered a weak estrogen in fish, but the effects of this chemical on early developmental events are far from clear. We tested the hypothesis that BPA accumulation in eggs, mimicking maternal transfer, disrupts growth hormone/insulin-like growth factor (GH/IGF) axis function, leading to defects in larval growth in rainbow trout. Trout oocytes were exposed to 0 (control), 0.3, 3, and 30 μg ml−1 BPA for 3 h, which led to an accumulation of around 0, 1, 4 and 40 ng BPA per egg, respectively. (…)

Oana Birceanu, Mark R. Servos, Mathilakath M. Vijayan, Aquatic Toxicology, Volume 161, Pages 51–60, April 2015

The article


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